CHUGR

Centre Hospitalier Universitaire de Grenoble

Structure involved

Institute for Advanced Biosciences (IAB)

Principal Investigator: Dr. Arnaud Millet

Arnaud Millet is a young group leader at Inserm where he is a permanent researcher in the Institute for Advanced Biosciences and a practitioner attached to the research department of the University Hospital located in Grenoble, France. He obtained a Ph.D. in immunology at Cochin Institute in Paris and a M.D. in internal medicine at the University Hospital of Rennes. Prior to completing his medical training, Dr. Millet obtained a master degree in Physics and in History and Philosophy of Science at the Ecole Normale Supérieure de Paris-Saclay. His research program is focused on the interplay between the mechanobiology of macrophages and their immune functions in chronic inflammatory diseases.

Scientific note: Our research project is devoted to the understanding of the influence of the physical environment on the ontogenesis and functions of human macrophages in the context of cancer. This project addresses the question of the influence of the tissular physical environment on immune functions of macrophages. In this project, we use 3D hydrogels based culture of human macrophages, tumorous spheroids and culture of tissue explant from patients to decipher how the modification of physical parameters the cross talk between macrophages and their cellular partners like cancer cells.

E-mail: arnaud.millet@inserm.fr

Links

Lab webpage: https://iab.univ-grenoble-alpes.fr/Team_MILLET_EN

Project

ESR6: Nano-mechanical signature of cancerous tissues and its relation to the associated immune response.