Tissue and ECM mechanical fingerprints of lung cancer
1st June 2019
To define differential mechanical properties of tissue and extracellular matrix (ECM) of lung clinical biopsies performed for lung cancerdiagnosis.
The study will be carried out in tissue samples obtained from biopsies performed for lung cancer diagnosis at the Clinic Hospital of Barcelona (affiliated with UB). Standardised protocols for preparation of lung tissue samples obtained from biopsies for AFM measurements. Characterisation of viscoelastic properties of normal and cancer lung ECM and tissue. Mechanical heterogeneity of normal and cancer lung tissues. Correlation between mechanical properties, molecular composition and structure of ECM of normal and cancer lung tissues. Mechanical fingerprints of parenchymal tissue and acellular ECM in patients with lung cancer.
Short biographic note