Biomechanics in health and disease:
advanced physical tools for innovative early diagnosis
H2020-MSCA-ITN-2018 n. 812772

ESR2. Ewelina Lorenc

Short biographic note

Ewelina.Lorenc_photo_small Ewelina is a young scientist from Poland. She obtained bachelor of engineering degree in biotechnology and master degree in molecular biotechnology at Jagiellonian University in Cracow.

During her master's studies, Ewelina worked on alternative doxorubicin therapy of lung cancer. She also broadened her knowledge and skills during international training and internships.

She is doing her PhD as a Marie-Curie Early Stage Researcher at the Department of Physics/CIMaINa at the University of Milan.
As participant of the Phys2BioMed project, Ewelina will investigate the relation between mechanical properties of the extracellular matrix (ECM), and the development and progression of diseases.




Project Title

Nano-mechanical fingerprints of extracellular matrices from healthy and tumoural tissues

Start date

1st July 2019




To investigate the relation between the mechanical properties of the extracellular matrix (ECM), and the development and progression of diseases (with focus on bladder cancer): to develop a standardised approach for the nano-mechanical characterisation of ECM samples from clinical tissues.

Expected Results

During this project the ESR will investigate the mechanical fingerprints of diseases, focusing in particular on bladder cancer, in collaboration with Ospedale San Raffaele (OSR). To this purpose, the ESR will contribute developing and validating sample preparation protocols for ECM derived from clinical tissues, in close collaboration with medical partners. Samples will be studied primarily by AFM-based indentation, but also by complementary correlative techniques. The cellular component of tissues will be studied also by microfluidic cytometry. The ESR will participate to the network-wide standardisation effort at the clinical level. The ESR will be involved actively on several network tasks in training, dissemination and communication, and will support coordination activities of the PI.

Planned secondments

Friedrich-Alexander-Universität Erlangen-Nürnberg FAU (Germany), elasticity study of suspended cells by fluidic cytometry; IBEC (Spain),mastering frequency-dependent AFM indentation measurements; IFJPAN (Poland), mechanical signature of disease in ECMs; BioMeca SAS (France), sample preparation procedures for ECMs and cells, and data analysis; TMT-C2RC (France), , mastering sample preparation techniques with clinical tissues; CNRS (France), correlative techniques complementary to AFM.