Biomechanics in health and disease:
advanced physical tools for innovative early diagnosis
H2020-MSCA-ITN-2018 n. 812772

ESR5. Maria Luisa Marini

Short biographic note


 Maria Luisa has always been interested in studying, and possibly creating, something that could change people’s lives. Therefore, she chose as bachelor degree biomedical engineering, at the Polytechnic University of Turin. Such course led her to discover the field of Lab-on-Chip systems with an elective internship. It was so challenging and interesting the application of such technologies that she undertook the path of the nanotechnologies, where it was possible to develop skills in solid-state physics and the electronic properties of materials, physics and manufacturing process techniques, as well as modelling and applications to MEMS, NEMS, transistors and photonic devices. The most challenging experience came along when the opportunity to work at DTU (Technical University of Denmark), building a prototype of a Gut-on-Chip that could integrate in vivo confluence analyses and diffusion studies. The project consisted in managing from the design to the fabrication and then testing of the prototype, exploiting deep imaging techniques, cell culture techniques and procedures, biology, biochemistry, galvanostatic acquisitions and 3D printing techniques. Even if Maria Luisa spent almost one year working in a consulting company, the research in life sciences has her curiosity and passion. In the Phys2BioMed project she will develop instrumentation and analysis tools for studying nano-mechanics parameters of cells and tissues.

Project Title

Nano-mechanics response measurements of cells and tissues in cancer

Start date

1st June 2019




Measuring nano-biomechanics of cells and tissues based on correlative approaches

Expected results

The ESR will participate in the development of instrumentation, sample preparation and analysis tools for measuring nano-mechanics parameters of cells/tissues including using automated multi-sample. He/She will use micro-patterns and micropillars substrata. He/She will apply this method to various cell types and tissue collected from patients suffering from colon or kidney cancer. The ESR will also be involved in science communication, training and dissemination

Planned secondments

1. INSERM, F. Rico (month 12,6 months). Use of complementary micro-patterned substrata and analysis tools; 2. WWU, H. Schillers (month 24,2 months). Preparation of complementary approaches for cell preparation. 3. O11, D. Iannuzzi (month 32, 2 months). Use of  nano-indentation tools as complementary approach.


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